The clinical research of D-dimer and fibrinogen concentration in plasma of patients with first-episode schizophrenia
10.3969/j.issn.1673-4130.2017.18.012
- VernacularTitle:首发精神分裂症患者血浆D-二聚体和纤维蛋白原水平的临床研究
- Author:
Ying YU
1
;
Leiming MAO
;
Ze HE
;
Yajun SUN
Author Information
1. 南通市第四人民医院检验科
- Keywords:
schizophrenia;
D-Dimer;
fibrinogen;
coagulation mechanism
- From:
International Journal of Laboratory Medicine
2017;38(18):2532-2533,2536
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the level and clinical significance of D-dimer(D-D) and fibrinogen(Fib) in patients with first-episode schizophrenia.Methods The 83 patients with first-episode schizophrenia from March 2014 to December 2016 were selected as the study group,meanwhile 58 healthy subjects without mental illness and major somatic diseases were selected as control group.Two groups of subjects were collected from fasting sodium citrate anticoagulated plasma to detect level of D-D and Fib.Resuits The level of D-D in the first-episode schizophrenia group was(240.42±245.78)μg/L,which was significantly higher than that in the control group(76.53±71.25)μg/L,and the difference was statistically significant(P＜0.05).While the level of Fib in the first-episode schizophrenia group (2.62 ± 0.49) g/L was significantly lower than that of the control group (2.87 ± 0.65) g/L,and the difference was statistically significant(P＜0.05).The increase in D-D levels and the reduction in Fib levels in patients with firstepisode schizophrenia were not related to gender.Conclusion he patients with first-episode schizophrenia in acute stage may have hypercoagulable status and secondary fibrinolysis.
