Relationship between changes of serum IL-34, RF and RANKL levels in patients with rheumatoid arthritis and osteoporosis
10.3969/j.issn.1673-4130.2017.18.015
- VernacularTitle:类风湿关节炎患者血清炎症因子与骨质疏松的关系
- Author:
Hongxiao LIN
1
;
Dongyan WANG
Author Information
1. 连云港市第一人民医院骨质疏松科
- Keywords:
rheumatoid arthritis;
osteoporosis;
interleukin-34;
rheumatoid factor;
NF-κB receptor activator ligand
- From:
International Journal of Laboratory Medicine
2017;38(18):2540-2542
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate and analyze the changes of serum interleukin-34(IL-34),rheumatoid factor(RF) and nuclear factor κB receptor activator ligand(RANKL) in patients with rheumatoid arthritis Its relationship with osteoporosis.Methods A total of 40 patients suffering from rheumatoid arthritis in the hospital between January 2016 and January 2017 were included in the study group,and 40 healthy subjects who underwent the same period of physical examination at the same time were enrolled as controls.By enzyme-linked immunosorbent assay(ELISA) were detected in 2 groups of serum IL-34 and RANKL levels were detected by latex agglutination assay of serum RF levels in 2 groups,and routine testing in patients with bone mineral density,erythrocyte sedimentation rate(ESR),C reactive protein(CRP) and anti CCP antibody.And the modified DAS28 score of disease activity of rheumatoid arthritis evaluation.Results The levels of serum IL-34,RF and RANKL in the study group were significantly higher than those in the control group(P＜0.05).The incidence of osteoporosis in the study group was significantly higher than that in the control group(P＜0.05).The levels of IL-34,RF and RANKL in the osteoporosis patients were significantly higher than those in the normal group(P＜0.05).The Spearman correlation analysis showed that the serum IL-34 levels were positively correlated with ESR,CRP,anti-CCP and DAS28 (P＜ 0.05).There was a negative correlation between serum IL-34,RF and RANKL levels and bone mineral density(P＜0.05).Conclusion The levels of serum IL-34,RF and RANKL in patients with rheumatoid arthritis were significantly increased,and the above indexes were negatively correlated with bone mineral density.It suggested that IL-34 may be involved in osteoporosis.
