Pyruvate substituting lactate dialysis solution peritoneal resuscitation on the effects of hemorrhagic shock rabbit liver function
10.3969/j.issn.1006-5725.2017.17.006
- VernacularTitle:丙酮酸盐替代乳酸盐腹膜透析液腹腔复苏对失血性休克家兔肝脏功能的影响
- Author:
Xingjun LUO
1
;
Ran RAN
;
Heying ZHONG
;
Gang TIAN
;
Daolin JIAN
;
Jie XU
Author Information
1. 湖北医药学院附属人民医院麻醉科
- Keywords:
hemorrhagic shock;
pyruvate;
peritoneal resuscitation;
liver function
- From:
The Journal of Practical Medicine
2017;33(17):2830-2833
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of direct peritoneal resuscitation on liver function in hemorrhagic shock rabbits with pyruvate peritoneal dialysis solution instead of lactate peritoneal dialysis solution. Methods 48 hemorrhagic shock rabbits were randomly divided into conventional intravenous resuscitation group (group A),intravenous resuscitation plus intraperitoneal injection of lactate peritoneal dialysis solution group (group B),intravenous resuscitation plus intraperitoneal injection of pyruvate peritoneal dialysis group(group C), intravenous pyruvate peritoneal dialysis resuscitation plus intraperitoneal injection of pyruvate peritoneal dialysis group(group D). The hemodynamic changes were observed and the AST and ALT were measured respectively before and 60 min after shock ,60 min and 180 min after resuscitation. The dry/wet weight ratio ,MDA and SOD of liver tissue were measured,and the liver morphological changes were observed. Results After the completion of shock resuscitation,MAP of all groups were almost restored to the basal level. 180 min after resuscitation,the MAP of animals in group A was lowered than that in group B,C and D(P<0.05). After shock,ALT and AST were signifi-cantly higher than those before shock ,but no significant difference was found between groups (P > 0.05). After resuscitation,ALT and AST continued to decline in all groups,but the decline range increased with the order of A, B,C,D group(P < 0.05). The water content and MDA in liver tissue decreased with the order of A,B,C,D group,while the SOD increased and the differences between groups were significant(P<0.05). And the degree of liver tissue morphological injury also relieved correspondingly. Conclusion Pyruvate substituting lactate peritoneal dialysis solution peritoneal resuscitation can be more effective in reducing liver damage of hemorrhagic shock rabbits.
