Clinical analysis of cyclophosphamide shock treatment in children with refractory nephropathy
10.3969/j.issn.1006-5725.2017.17.026
- VernacularTitle:环磷酰胺冲击治疗儿童难治性肾病的临床分析
- Author:
Xun CHEN
1
;
Haixia SU
;
Yuanhan QIN
Author Information
1. 广西医科大学第一附属医院儿科
- Keywords:
refractory nephrotic syndrome;
children;
cyclophosphamide;
pulse therapy;
hormone
- From:
The Journal of Practical Medicine
2017;33(17):2907-2910
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect and adverse reactions of intravenous cyclophosphamide (CTX) pulse therapy on refractory nephrotic syndrome (RNS) in children. Methods Retrospective study was carried on 102 patients with RNS treated with high dose CTX impact treatment in The First Hospital Affiliated to Guangxi Medical University from August 2006 to August 2016. Clinical data and follow-up records were analyzed. Results Biochemical indicators significantly improved after treatment ,and the difference was statistically signifi-cant(P < 0.05). Fifty-six patients achieved complete remission,and 21 patients achieved partial remission,with an effective percentage of 75.5%,and adverse drug reactions incidence rate of 19.6%. There was not significant difference in the remission rate of different clinical types. Conclusions High dose of CTX shock treatment on children refractory nephrotic syndrome is effective ,with low adverse reactions incidence.
