Acute Toxicity Study of Solanumprocumbens Traditional Zhuang Medicine
10.3870/j.issn.1004-0781.2017.11.009
- VernacularTitle:壮药海南茄急性毒性研究
- Author:
Zengyan YANG
1
;
Xiangpei ZHAO
;
Shaofeng CHEN
;
Xin HUANG
;
Ruisong HUANG
Author Information
1. 广西民族医药研究院
- Keywords:
Solanumprocumbens;
Toxicity acute;
LD50
- From:
Herald of Medicine
2017;36(11):1253-1254
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety of Solanumprocumbens by studying its acute toxicity to mice. Methods The dosage of 100% death ( Dm) and 100% survive ( Dn) were determined. Five groups were set between the dosage of Dm and Dn in a 1:0.8 ratio, and then were intragastrically administrated once at the dosage of 250,200,160,128,102.4 g·kg-1 respectively.Toxicity and mortality of mice after intragastricly administration of Solanumprocumbens were observed for 14 days continuously. Results After four hours of administration, there were death in each group except the lowest dosage group (102.4 g·kg-1).Number of death of the groups 250,200,160 and 128 g·kg-1 were 10,8,6 and 3 respectively.LD50 of Solanumprocumbens was 153. 02 g · kg-1 , the 95% confidence interval was ( 136. 55, 171. 47 ) g · kg-1 . Conclusion Solanumprocumbens has a certain toxicity.More attention should be payed to its toxicity for clinical rational drug use.
