Expressions of Tim-3 and CD4+and CD8+T cells in peripheral blood from patients with coronary heart dis-ease
10.3969/j.issn.1006-5725.2017.17.010
- VernacularTitle:冠心病患者外周血Tim-3及CD4+、CD8+的表达
- Author:
Ying WANG
1
;
Xiuwen KANG
;
Jiye LUO
;
Delu YIN
;
Xiaomin LI
Author Information
1. 222002,江苏省连云港市第一人民医院心内科
- Keywords:
coronary heart disease;
Tim-3;
CD4+;
CD8+
- From:
The Journal of Practical Medicine
2017;33(17):2847-2849
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of T cell immunoglobulin and mucin-domain contain-ing moleculesfamily-3(Tim-3)and CD4+ and CD8+ T cells in peripheral blood from patients with coronary heart disease (CHD). Methods 51 CHD patients were divided into two groups:stable angina pectoris group (27 patients)and acute coronary syndromes group(24 patients). Another 25 healthy subjects confirmed by coronary angiography were selected as a control group. Peripheral blood was drawn on admission. Enzyme-linked immunosor-bent assay was used to detect the concentration of Tim-3. Flow cytometry was applied to detect the expressions of CD4+and CD8+. Results As compared with the healthy control group ,the concentration of Tim-3 and the propor-tion of CD8+ in stable angina pectoris group and acute coronary syndrome group were reduced ,and those in acute coronary syndrome group were lower. The differences were statistically significant (P < 0.05). As compared with the healthy control group,the proportion of CD4+ and the ratio of CD4+/CD8+ of stable angina pectoris group and acute coronary syndrome group were increased ,while those in acute coronary syndrome group were higher. The differences were statistically significant(P<0.05). Conclusions At the onset of CHD,the concentration of Tim-3 and the proportion of CD8+ in peripheral blood are reduced ,but the proportion of CD4+ is increased. The more severe the disease,the greater changes the values.
