Relationship between type 2 diabetes mellitus and serum stromal cell derived factor 1 levels
10.3969/j.issn.1006-5725.2017.17.034
- VernacularTitle:2型糖尿病与血清基质细胞衍生因子-1水平的相关性
- Author:
zhou Qiong YIN
1
;
Kexin SUN
;
Zhike LIU
;
Juan JUAN
;
Xiao XIANG
;
Jin LI
;
Tao WU
;
Dafang CHEN
;
Yonghua HU
Author Information
1. 北京大学公共卫生学院
- Keywords:
type 2 diabetes mellitus;
stromal cell derived factor-1;
macrovascular complications
- From:
The Journal of Practical Medicine
2017;33(17):2939-2942
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between type 2 diabetes mellitus(T2DM)and serum stromal cell derived factor-1(SDF-1)levels. Methods A community-based epidemiological field study for T2DM patients and non-T2DM subjects was conducted in Beijing,China. Every subject underwent physical examinations, biochemical tests of stromal cell derived factor 1 and so on,and completed a standardized questionnaire. A total of 756 subjects were recruited in our analysis ,including 267 T2DM patients and 489 non-T2DM subjects ,T2DM patients were further divided into 81 simple T2DM patients and 186 macrovascular complication patients on the basis of the status of macrovascular complication. The correlation between serum SDF-1 levels and T2DM was analyzed. Results Compared with non-T2DM group,the level of SDF-1 in T2DM group was higher(P=0.019). The level of SDF-1 in simple T2DM group was also higher than macrovascular complication group(P=0.044). In the multi-ple linear regression analysis,after adjustment for age,gender,smoking,drinking,dyslipidemia,hypertension and BMI,SDF-1 level in simple T2DM group was higher than macrovascular complication group(P = 0.049), still. Conclusions Simple T2DM patients had a higher serum SDF-1 level than T2DM patients with macrovascular complications as well as those who did not suffer T2DM,suggesting that the stromal cell derived factor-1 may play a certain role in the development of T2DM and macrovascular complications.
