Optimization of the Penetration Enhancers for Xiaochuan Emplastrum
10.3870/j.issn.1004-0781.2017.11.024
- VernacularTitle:消喘贴敷膏剂促渗剂优选
- Author:
Youfeng WANG
1
;
Bing WANG
;
Yunfei CAO
;
Wei ZHANG
;
Xiaoying BAI
Author Information
1. 山东中医药大学药学院
- Keywords:
Xiaochuan Emplastrum;
Chromatography;
high performance liquid;
Penetration enhancer;
Sinapine thiocyanate
- From:
Herald of Medicine
2017;36(11):1306-1309
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate and optimize the penetration enhancers of Xiaochuan emplastrum. Methods Franz diffusion cell was employed with isolated mice abdominal skin as barrier. The accumulating osmotic quantity per unit area and penetrating absorption rate of Sinapine thiocyanate were determinated by HPLC method. The penetration enhancers were selected and the ratio was determined. Results Combination of azone and propylene glycol were better than other kinds of enhancers for penetration effect, the ratio of propylene glycol and azone was 2:1. Dosage of azone and propylene glycol was finally optimized to 5% of prescription dosage.Under these conditions, cumulative permeation quantity of Sinapine thiocyanate was 369.59 μg·(cm2)-1, penetration rate of Sinapine thiocyanate was 14.19 μg·(cm2)-1·h-1 and enhancing rate was 3.19. Conclusion The ratio of propylene glycol and azone was 2:1,dosage of azone and propylene glycol was 5% of prescription dosage, which has a significant penetration effect and can be used as the penetration enhancer of Xiaochuan emplastrum.
