Research progress of humanized mouse models in immune system
10.3969.j.issn.1671-7856.2017.10.022
- VernacularTitle:免疫系统人源化小鼠模型的研究进展
- Author:
yao Jing LIAN
1
;
hui Miao DING
;
hui Guo QIN
;
yi ZHANG
;
yao Chun WANG
Author Information
1. 郑州大学第一附属医院
- Keywords:
Humanized mouse models;
Human diseases
- From:
Chinese Journal of Comparative Medicine
2017;27(10):113-119
- CountryChina
- Language:Chinese
-
Abstract:
Animal model is an animal material with human mimic performance established in biomedical scientific research. It can be used as experimental basis for studies of experimental hypothesis and clinical hypothesis. It can shorten the research time and observe the whole process of disease occurrence, development or prevention and treatment. Human biomedical research is largely limited by the biological complexity. In order to overcome this limitation, based on the immunosuppressive characteristics of a severely immunodeficient ( SCID) or recombinant activated gene ( Ragnul ) in mice, humanized mouse models of human diseases can be established and have been widely used to study the underlying principles of human immunobiology and complex pathological mechanisms of human diseases. This approach has become one of the important ways to promote the development of medical sciences, with practicality and foresight. In this paper, the application and research progress of humanized mouse models are reviewed.
