Expressions of peroxisome proliferator-activated receptor γ, retinoic acid X receptor α and cyclooxygenase 2 in cervical squamous cell carcinoma and their significances
10.3760/cma.j.issn.1006-9801.2017.10.003
- VernacularTitle:子宫颈鳞状细胞癌中过氧化物酶体增殖物激活受体γ、维甲酸类X受体α及环氧合酶2的表达及其意义
- Author:
Fang LI
1
;
Xianghong ZHANG
;
Feiyan ZHANG
;
Xiaodan GUO
;
Zhenyu MA
;
Wei ZHANG
Author Information
1. 071051,河北省保定市第二医院病理科
- Keywords:
Uterine cervical neoplasms;
Carcinoma;
squamous cell;
Squamous intraepithelial lesion;
Peroxisome proliferator-activated receptorγ;
Retinoic acid X receptorα;
Cyclooxygenase 2
- From:
Cancer Research and Clinic
2017;29(10):658-662
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the functions of peroxisome proliferator-activated receptorγ(PPARγ), retinoic acid X receptor α (RXRα) and cyclooxygenase 2 (COX-2) in the carcinogenesis of cervical squamous cell carcinoma (SCC). Methods The expressions of PPARγ, RXRα and COX-2 in 17 cases of normal cervical epithelium (NCE), 72 cases of squamous intraepithelial lesion (SIL) and 42 cases of cervical SCC were detected with immunohistochemical method respectively. Results The positive expression rates of PPARγ in the NCE, SIL and cervical SCC group were 23.5 % (4/17), 58.3 % (42/72) and 83.3 % (35/42) respectively; the positive expression rates of RXRα in the NCE, SIL and cervical SCC group were 29.4 %(5/17), 54.2 % (39/72) and 90.5 % (38/42) respectively. No significant expression of COX-2 was found in the NCE, while the positive expression rates of COX-2 in SIL and cervical SCC were 36.1 % (26/72) and 57.1 %(24/42) respectively. The positive expression rates of PPARγ, RXRαand COX-2 in high-grade SIL group were higher than those in low-grade SIL group (all P<0.05). In cervical SCC group, the positive expression rate of COX-2 with lymph node metastasis was higher than that without lymph node metastasis (χ2= 3.98, P= 0.04). Conclusion PPARγ, RXRαand COX-2 might be all involved in the carcinogenesis of SCC.
