Progress of metformin for treatment of breast cancer
10.3760/cma.j.issn.1006-9801.2017.10.020
- VernacularTitle:二甲双胍治疗乳腺癌的研究进展
- Author:
Junhong ZHUANG
1
Author Information
1. 150086,哈尔滨医科大学附属第二医院肿瘤内科
- Keywords:
Breast neoplasms;
Metformin;
Diabetes mellitus;
Research
- From:
Cancer Research and Clinic
2017;29(10):717-720
- CountryChina
- Language:Chinese
-
Abstract:
Metformin is a first-line drug treatment for typeⅡdiabetes. Recent studies have showed that metformin can upregulate CycG2, induce mitochondria-mediated accumulation of reactive oxygen species (ROS), and inhibit the activity of transforming growth factor-β (TGF-β). Metformin could protect metastasis of nondiabetic breast cancer, and may become a chemopreventive drug for breast cancer. This review aims to clarify the inhibitory mechanism of metformin on the breast cancer and the drug resistance of metformin according to basic and clinical study.
