A Case of Anticonvulsant Hypersensitivity Syndrome thought to be Caused by Lamotrigine.
- Author:
Jung Eun LEE
1
;
Bon Cheol GOO
;
You Chan KIM
;
Ju Hee LEE
;
Kwang Hoon LEE
Author Information
1. Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea. kwanglee@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Anticonvulsant hypersensitivity syndrome (AHS);
Lamotrigine
- MeSH:
Adult;
Anticonvulsants;
Carbamazepine;
Erythema Multiforme;
Exanthema;
Fever;
Hepatitis;
Humans;
Hypersensitivity*;
Phenobarbital;
Phenytoin
- From:Korean Journal of Dermatology
2006;44(5):620-623
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anticonvulsant hypersensitivity syndrome (AHS) is a rare and potentially life-threatening drug reaction, which has been associated with aromatic anticonvulsants such as phenytoin, carbamazepine, and phenobarbital. It is characterized by the triad of fever, rash and internal organ involvement, which mostly includes hepatitis. Histopathological findings usually show characteristic erythema multiforme. Lamotrigine is a new antiepileptic drug, chemically distinct from other anticonvulsant medication, however, AHS has recently been documented in patients treated with lamotrigine. We report a case of AHS in a 29-year-old man, thought to have been caused by the use of lamotrigine.
