Amyotrophic lateral sclerosis-associated gene mutations and ALS animal models
10.3969.j.issn.1671-7856.2017.10.018
- VernacularTitle:肌萎缩侧索硬化症相关基因突变与疾病动物模型
- Author:
Li ZHANG
1
;
feng Lian ZHANG
Author Information
1. 中国医学科学院
- Keywords:
Amyotrophic lateral sclerosis;
Gene mutation;
Animal model
- From:
Chinese Journal of Comparative Medicine
2017;27(10):89-95
- CountryChina
- Language:Chinese
-
Abstract:
Amyotrophic lateral sclerosis ( ALS ) is a progressive neurodegenerative disease characterized by a selective loss of upper and lower motor neurons that lead to paralysis and even death. Mutations in a large number of genes, including FUS/TLS, EPHA4, SS18 L1, ATXN2 and C9ORF72, are identified to the casual genes of ALS, which broadens our understanding of the role of RNA modulation in ALS pathogenesis. This review summarized ALS-associated genes and the related ALS rodent models.
