Genotoxicity of Sanqi Liver-protecting Capsules
- VernacularTitle:三七护肝胶囊的遗传毒性评价
- Author:
Yang WANG
1
;
Kaiyong HE
;
Jiate SHEN
;
Yan WANG
;
Xiaojun LV
Author Information
1. 湖北省药品监督检验研究院 武汉430064
- Keywords:
Sanqi liver-protecting capsules;
Acute toxicity;
Genotoxicity
- From:
China Pharmacist
2017;20(10):1749-1752
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the acute toxicity and genotoxicity of Sanqi liver-protecting capsules to evaluate the toxicological safety. Methods:The mouse acute oral toxicity test, Ames test, micronucleus test of mouse bone marrow and mouse sperm shape ab-normality test were carried out for Sanqi liver-protecting capsules. Results:The mouse acute oral maximum tolerance dose ( MTD) of Sanqi liver-protecting capsules was above 20 g·kg-1 in the mouse acute oral toxicity test, which showed a non-toxic substance. The results of Ames test, micronucleus test of mouse bone marrow and mouse sperm shape abnormality test were negative in all the groups. Conclusion:Under the above experimental conditions,the genotoxicity of Sanqi liver-protecting capsules is not found out, therefore, the capsules are classified as a non-toxic drug.
