Radiological Findings of Chronic Granulomatous Disease of Childhood.
10.3348/jkrs.1994.30.4.763
- Author:
Woo Sun KIM
;
Jin Mo GOO
;
In One KIM
;
Kyung Mo YEON
- Publication Type:Original Article
- MeSH:
Angiography, Digital Subtraction;
Brain;
Diagnosis;
Granulomatous Disease, Chronic*;
Humans;
Infant;
Lymph Nodes;
Meningitis;
Nitroblue Tetrazolium;
Osteomyelitis;
Pneumonia;
Radiography, Thoracic;
Respiratory System;
Retrospective Studies;
Thorax;
Tomography, X-Ray Computed
- From:Journal of the Korean Radiological Society
1994;30(4):763-769
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Chronic granulomatous disease(CGD) is a group of genetic disorders characterized by recurrent pyogenic infections of the respiratory tract, skin,and soft tissue. The aim of this study is to describe the radiological findings of CGD. MATERIALS AND METHODS: We retrospectively analyzed radiological findings of 11 patients of CGD, which were diagnosed by nitroblue tetrazolium test. We analyzed the pattern of pneumonia on chest radiograph in all infants. Three cases of chest CT and one case of digital subtraction angiography were performed. According to infant's symptom, abdominal ultrasonography(n=8), abdominal CT(n=5), simple bone radiography(n=2), and brain CT(n=I) were performed. RESULTS: Repeated infiltration(100%), mass-like consolidation(73%), hilar or mediastinal lymph node enlargement(64%), scattered nodules(55%), cavity formation(27%), and pleural effusion(27%) were found on the chest radiographs(n=11) and CT(n=3). On the abdominal imagings(n=8), there were hepatosplenomegaly(n=6), calcifications in the liver(n=2) and kidney(n=1), hepatic granuloma(n=1) and renal abscess(n=1). Two patients had osteomyelitis. There were findings of meningitis on brain CT(n=1). CONCLUSION: We believe that the combinations of these radiological findings may suggest the diagnosis of CGD in patients with history of reccurent infection.
