Research Progress in β-Glucuronidase
- VernacularTitle:β-葡萄糖醛酸苷酶的研究进展
- Author:
Xixi HUANG
1
;
Yani LIU
;
Shaojun SHI
Author Information
1. 华中科技大学同济医学院附属协和医院药剂科 武汉430022
- Keywords:
β-Glucuronidase;
Crystal structure;
Mutation;
Function
- From:
China Pharmacist
2017;20(10):1834-1838
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the structure, properties and biological functions ofβ-glucuronidase. Methods:By referring to the relevant literatures at home and abroad onβ-glucuronidase in recent years, this paper induced, analyzed and drew conclusions. Results:The crystal structure of humanβ-glucuronidase is comprised of three distinct structural domains. The most common mutation of β-glucuronidase is missense mutation, which results in the change of enzyme activity, and then induces a series of pathological chan-ges like MPSⅦ. The researches on β-glucuronidase used in antibody-directed enzyme prodrug drug therapy and enzyme replacement therapy are becoming deeper and deeper. Conclusion:β-Glucuronidase as an important acid hydrolytic enzyme in human has a variety of genetic mutations, and plays an important role in the fields of medicine and disease diagnosis, which has become one of research hotspots.
