Clinical and pathological analysis of epithelioid glioblastoma: a report of 4 cases
10.3969/j.issn.1002-0152.2017.08.003
- VernacularTitle:上皮样胶质母细胞瘤4例临床病理分析
- Author:
Hainan LI
1
;
Minting LIU
;
Lina CHENG
;
Zhenbin ZHANG
;
Li YANG
;
Wensheng WANG
;
Guangyu JIANG
;
Zhi LI
Author Information
1. 广东三九脑科医院病理科 广州510510
- Keywords:
Brain neoplasm;
Glioblastoma;
Pathology;
Diagnosis;
Differential
- From:
Chinese Journal of Nervous and Mental Diseases
2017;43(8):458-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the neuroimaging and pathological features of epithelioid glioblastoma (EGBM) to improve the diagnosis.Methods The clinical and pathological features of 4 E-GBM cases were analyzed retrospectively.Results E-GBMs occurred predominantly in young adults.MRI examination showed irregular solidcystic lesion with heterogeneous or ring enhancement in 4 cases.Histological examination revealed uniform population of epithelioid or rhabdoid cells with prominent nucleoli and mitotic activity as well as geographic necrosis..Immunohistochemical staining showed various positive signals of Vimentin and S-100 protein in 4 cases,positive signal of BRAF (VE1) in 3 cases and focal positive signal of GFAP in 1 case.However,IDH-1 was negative and 1p/19q codeletion was lack.All patients were followed-up for 2-6 months.One patient had tumor recurrence 3 months and one patient died of disease 6 months after surgical excision.Conclusion E-GBM has a poor outcome and is closely associated with pleomorphic xanthoastrocytoma.MRI and epithelioid histological features are very important for the differential diagnosis.
