Anti-platelet/anti-coagulation and their prognosis in advanced aged patients with ACS complicated atri-al fibrillation after PCI
10.3969/j.issn.1008-0074.2017.05.15
- VernacularTitle:高龄急性冠脉综合征并房颤患者PCI术后抗血小板/ 抗凝与预后
- Author:
lin Zhen WU
1
;
wei Jia CHEN
;
ying Cong MA
;
fang Fang ZHOU
;
lin Chang LU
Author Information
1. 河北燕达医院心脏中心
- Keywords:
Atrial fibrillation;
Brain ischemia;
Acute coronary syndrome
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(5):515-518
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore anti-platelet/anti-coagulation treatment and their influence on prognosis in advanced aged patients with acute coronary syndrome (ACS)complicated atrial fibrillation (AF)after percutaneous coronary intervention (PCI).Methods:A total of 204 advanced aged ACS + AF patients treated in our heart center were se-lected.All patients received CHA2 DS2 Vasc score assessment,male had score ≥2 scores and female had score ≥3 scores.A total of 160 cases received dual anti-platelet therapy combined anticoagulant treatment of warfarin,and they were randomly divided into low intensity group [n=80,international normalized ratio (INR)remained 1.8~2.3]and high intensity group (n=80,INR remained 2.3~2.8),both groups were followed up for 18 months.Inci-dence rates of major adverse cardiovascular and cerebrovascular events (MACCE),ischemic and hemorrhage events were observed.Results:Both groups were followed up for a mean 18 months,and there were no significant differ-ence in all-cause mortality,incidence rates of MACCE and fatal hemorrhage between two groups,P > 0.05 all.Compared with low intensity group,there were significant rise in incidence rates of severe hemorrhage (3.8% vs. 12.5%),P <0.05.Conclusion:Low intensity warfarin anticoagulant therapy can effectively reduce incidence rates of MACCE and ischemic events,and incidence rate of hemorrhage events is low in advanced aged ACS + AF pa-tients after PCI.
