Influence of furosemide combined Xinmailong injection on LVEF and blood lactate in patients with chronic heart failure
10.3969/j.issn.1008-0074.2017.05.19
- VernacularTitle:呋塞米并心脉隆注射液对心衰患者左室射血分数及 血乳酸的影响
- Author:
hua Bang HE
1
Author Information
1. 宁德市周宁县医院心血管内科
- Keywords:
Furosemide;
Heart failure;
Lactic acid
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(5):529-533
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study influence of furosemide combined Xinmailong injection on left ventricular ejection fraction (LVEF)and blood lactate level in patients with chronic heart failure (CHF),and explore its therapeutic effect.Methods:Clinical data of 95 CHF patients treated in our hospital were retrospectively analyzed,including 48 cases using furosemide therapy (furosemide group),and 47 cases using furosemide combined Xinmailong injection (combined treatment group),both groups were treated for 15d.Therapeutic effect,LVEF, blood lactate and CA125 levels after treatment were compared between two groups.Results:Total effective rate of combined treat-ment group was significantly higher than that of furosemide group (87.23% vs.64.58%),P =0.01;compared with furosemide group after treatment,there were significant rise in LVEF [(49.6±3.6)% vs.(54.5±3.9)%],6min walking distance [(274.4±38.9)m vs.(359.5 ± 56.4)m]and maximum metabolic equivalent [(32.4 ±3.9 ) METs vs.(39.8±3.6)METs],and significant reductions in levels of blood lactate [(1.2±0.5)mmol/L vs.(0.7 ±0.3)mmol/L],CA125 [(55.6±6.9)IU/ml vs.(42.3±5.8)IU/ml],N-terminal pro brain natriuretic peptide [(2345.4±338.6)pg/ml vs.(1689.6±226.9)pg/ml]and serum uric acid [(402.4±43.9)mol/L vs.(359.8± 53.7)mol/L]in combined treatment group,P = 0.001 all.No severe adverse reactions occurred in two groups. Conclusion:Furosemide combined Xinmailong injection can significantly improve LVEF,reduce blood lactate level and improve heart function in CHF patients,and it′s safe and effective,which is worth extending in clinic.
