A Case of Successful Hemoperfusion in the Treatment of Acute Severe Clozapine Intoxication.
- Author:
Hwa Jong KIM
1
;
Su Ji KIM
;
Kwan Hyun LEE
;
Hyo Wook GIL
;
Jong Oh YANG
;
Eun Young LEE
;
Sae Yong HONG
Author Information
1. Division of Nephrology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea. eylee@sch.ac.kr
- Publication Type:Case Report
- Keywords:
Clozapine;
Hemoperfusion
- MeSH:
Agranulocytosis;
Arrhythmias, Cardiac;
Central Nervous System;
Clozapine;
Depression;
Hemoperfusion;
Humans;
Mood Disorders;
Respiratory Insufficiency;
Schizophrenia;
Seizures;
Stupor
- From:Korean Journal of Nephrology
2009;28(6):639-642
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Clozapine, a psychotropic drug commonly used in the treatment of schizophrenia or schizophrenic affective disorders may show side effects such as agranulocytosis, cardiomyositis, cognitive and motor depression in therapeutic doses and central nervous system depression, respiratory depression, arrhythmia, seizures, and even death in case of severe intoxication, warranting an aggressive treatment. We hereby report a case of clozapine overdose patient who ingested a potentially fatal dose of 3 grams and showed stuporous mental state, who was treated successfully by hemoperfusion without any sequelae.
