Relationship between subtypes of T follicular helper cells and unexplained recurrent spontaneous abortion

VernacularTitle:滤泡性辅助T细胞亚型与原因不明复发性流产的关系研究
Author: rui Xiao LUAN ¹ ; ping Wei LI
Author Information

1. 上海交通大学医学院附属仁济医院妇产科
Keywords: unexplained recurrent spontaneous abortion; T follicular helper; CXCR3; CCR6; decidua; flow cytometry
From: Journal of Shanghai Jiaotong University(Medical Science) 2017;37(10):1346-1349
CountryChina
Language:Chinese
Abstract: Objective · To discuss the relationship between unexplained recurrent spontaneous abortion (URSA) and T follicular helper (Tfh) cell subtypes. Methods · Twenty-eight normal early pregnancy women, who had undergone induced abortion, were taken as control, and 28 patients with URSA were enrolled in the abortion group. The mononuclear cells in peripheral blood and decidual tissues were separated in the two groups, and CXCR3+CCR6- Tfh cells, CXCR3-CCR6- Tfh cells, CXCR3-CCR6+ Tfh cells and B cells were tested by flow cytometry. Results · The decidual CXCR3-CCR6- Tfh cells significantly increased in the abortion group compared with control group (P=0.015). And there was a strong association between the decidual CXCR3-CCR6- Tfh cells and B cells in URSA patients (R2=0.779, P=0.025). Conclusion · The up-regulation of decidual CXCR3-CCR6- Tfh cells in early pregnancy women may be related with the occurrence of URSA.