Research progresses on the role of adiponectin and its receptors in prostate cancer
10.3969/j.issn.1674-8115.2017.10.025
- VernacularTitle:脂联素及其受体在前列腺癌中的作用和研究进展
- Author:
Shi FU
1
;
Juan ZHOU
;
Zhong WANG
Author Information
1. 上海交通大学医学院附属第九人民医院泌尿外科
- Keywords:
prostate cancer;
adiponectin;
obesity;
adiponectin receptors;
adiponectin deficiency
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2017;37(10):1434-1437
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer is a hormone-associated malignancy and is closely related to obesity in terms of epidemiology and molecular mechanisms.Adiponectin, an adipocytokine produced by adipokine and secreted by adipocyte, exhibits anti-inflammatory, insulin-sensitizing, anti-proliferation, and proapoptosis actions on various organs in an endocrine form. Obesity leads to a decrease in adiponectin level, which is closely associated with the occurrence of many tumors. Studies have showed that prostate cancer patients had lower serum adiponectin levels and decreased expression of adiponectin receptors in tumor tissues, which suggest that functional defects of adiponectin and its receptors may be relevant to the occurrence and development of prostate cancer.This paper reviews adiponectin and its receptors' functions, signaling pathways, and roles in diagnosis, treatment, and prognosis of prostate cancer.
