Biomedical effects of TRIP-Br2
10.3969/j.issn.1674-8115.2017.10.026
- VernacularTitle:TRIP-Br2的生物学作用
- Author:
ping Xin SHE
1
;
Zhi ZHENG
Author Information
1. 上海交通大学附属第一人民医院上海市眼底病重点实验室
- Keywords:
TRIP-Br2;
energy metabolism;
neoplasm;
inflammation
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2017;37(10):1438-1440
- CountryChina
- Language:Chinese
-
Abstract:
TRIP-Br2 (transcriptional regulator interacting with the PHD zinc finger and/or the bromodomain 2) is a kind of cell cycle regulator, which can specifically bind to transcription factor DP-1 (DRTF-1-polypeptide-1) and participate in E2F-1 (E2 factor-1)/DP-1-mediated transcriptional proliferative activities and maintain genome stability. As for energy metabolism, overexpression of TRIP-Br2 activates E2F-1/DP-1-mediated cell cycle regulation,leading to decreased genomic stability and promoting oncogenesis. High levels of TRIP-Br2 can induce brown adipocytes to release inflammatory factors and acute phase response proteins, producing inflammatory responses and acute phase responses. This paper summarizes the molecular structure of TRIPBr2 and its biological role in proliferation, metabolism, and inflammation.
