NF-κB participates in the regulation of apoptosis
10.3969/j.issn.1674-8115.2017.10.028
- VernacularTitle:NF-κB参与调控细胞凋亡
- Author:
xiao Xiao YANG
1
;
ting Hong HUANG
;
hua Man LIU
;
Ying HUANG
Author Information
1. 上海交通大学医学院附属仁济临床医学院
- Keywords:
NF-κB;
apoptosis;
signal conduction
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2017;37(10):1446-1452
- CountryChina
- Language:Chinese
-
Abstract:
The abnormal changes in the apoptosis activities are relevant to a number of diseases including the tumor genesis and development. Since the gene structure of NF-κB being cloned three decades ago, the investigation of the transcriptional factor has been improved over time. A series of target genes are revealed to be modulated, which participate in physiological and pathological activities, including inflammation, proliferation, differentiation,senescence, and apoptosis. This review is focused on the signaling network of cell apoptosis regulated by NF-κB, the molecular involved, as well as the environmental variants associated. Furthermore, as NF-κB is unusually up-regulated in diseases such as cancer, searching for its specific antagonists may prevent the occurrence of those diseases.
