Effects of Ephedrae Herba on plasma levels of three constituents in Glycyrrhizae Radix et Rhizoma
10.3969/j.issn.1001-1528.2017.10.004
- VernacularTitle:麻黄对甘草3个成分血药浓度的影响
- Author:
Ping WEI
1
;
hai Qin MA
;
yue Meng REN
;
bo Jia LUO
Author Information
1. 深圳市坪山区妇幼保健院
- Keywords:
Ephedrae Herba (Mahuang);
Glycyrrhizae Radix et Rhizoma (Gancao);
herbal pair;
glycyrrhizic acid;
glycyrrhetinic acid;
liquiritin;
pharmacokinetics
- From:
Chinese Traditional Patent Medicine
2017;39(10):2009-2014
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effects of the compatibility of Ephedrae Herba (Mahuang) and Glycyrrhizae Radix et Rhizoma (Gancao) on pharmacokinetic changes of the plasma levels of glycyrrhizic acid,glycyrrhetinic acid and liquiritin by UPLC-MS/MS.METHODS Twelve SD rats were randomly divided into two groups and orally administered with Glycyrrhizae Radix et Rhizoma and Ephedrae Herba-Glycyrrhizae Radix et Rhizoma (2 ∶ 1) Decoction.Blood samples were collected at different time points,and the main pharmacokinetic parameters were calculated by DAS3.2.2 software.RESULTS Compared with Glycyrrhizae Radix et Rhizoma group,the AUC0-t and Cmax were decreased,the MRT0-t and t1/2z were extended,the Vz/F was increased for glycyrrhizic acid,glycyrrhetinic acid and liquiritin;the CLz/F was increased for glycyrrhizic acid and liquiritin;the Tmax of glycyrrhizic acid was shortened and the Tmax of glycyrrhetinic acid was extended.CONCLUSION After combining Glycyrrhizae Radix et Rhizoma and Ephedrae Herba,the bioavailability of glycyrrhizic acid,glycyrrhetinic acid and liquiritin are reduced,the elimination of them delays,and the distribution volume increases.
