A Case of Post-transplant Lymphoproliferative Disorder Manifested as Native Kidney Mass.
- Author:
Ji Youn YU
1
;
Mi Youn PARK
;
Yeon Oh JEONG
;
Hae Kyung LEE
;
Ji Chan PARK
;
Sang Ju LEE
;
Yoon Kyung CHANG
;
Suk Young PARK
;
Suk Young KIM
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Korea. racer@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Lymphoproliferative disorder;
Kidney transplantation
- MeSH:
Bone Marrow;
Carcinoma, Renal Cell;
Herpesvirus 4, Human;
Humans;
Immunosuppression;
Immunosuppressive Agents;
Infectious Mononucleosis;
Kidney;
Kidney Transplantation;
Liver;
Lymphoma, B-Cell;
Lymphoproliferative Disorders;
Nephrectomy;
Organ Transplantation;
Palatine Tonsil;
Spleen;
T-Lymphocytes, Cytotoxic;
Transplants
- From:Korean Journal of Nephrology
2009;28(6):697-703
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Post-transplant lymphoproliferative disorder (PTLD) following solid organ transplantation is an important form of post-transplant malignancy. PTLD is typically associated with Epstein-Barr virus (EBV) and occurs in the setting of immunosuppression resulting in a deficiency of EBV-specific cytotoxic T lymphocytes. PTLD encompasses heterogeneous lymphoproliferative diseases, from polyclonal proliferation resembling infectious mononucleosis to aggressive monomorphic proliferation such as diffuse large B-cell lymphoma. Clinically, PTLD is usually manifested as lymph nodal mass or extranodal mass of solid organs such as liver, transplanted kidney, tonsil, bone marrow or spleen. The authors experienced very rare case of PTLD manifested as a single mass in a native kidney. According to a review of the literature, this is a rare case of PTLD which developed in a native kidney after kidney transplantation. Initially under the impression of renal cell carcinoma, unilateral nephrectomy of the native kidney had performed, and after confirmed as PTLD by histologic diagnosis the patient had treated with reduction of immunosuppressants and chemotheraphy for PTLD, and eventually has got in complete remission.
