Prognostic value of interim 18 F-FDG PET/CT in patients with natural killer/T cell lymphoma
10.3760/cma.j.issn.2095-2848.2017.10.004
- VernacularTitle:化疗中期18 F-FDG P ET/CT显像对自然杀伤/T细胞淋巴瘤的预后评价
- Author:
Qin HUANG
1
;
Hong LIU
;
Xiaofeng YANG
;
Yan LI
;
Xiaoyan ZHANG
;
Xiaomin WANG
Author Information
1. 新疆维吾尔自治区人民医院血液科
- Keywords:
Lymphoma,T-cell;
Prognosis;
Positron-emission tomography;
Tomography,X-ray computed;
Deoxyglucose
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2017;37(10):618-622
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic value of interim 18 F-FDG PET/CT scan in pa-tients with natural killer ( NK)/T cell lymphoma. Methods From January 2012 to May 2015, thirteen pa-tients (10 males, 3 females;mean age (43.85±7.66) years) underwent methotrexate+ifosfamide+etoposide+prednisone acetate+L-asparaginase ( SMILE ) chemotherapy. All patients underwent pre-, mid-treatment ( after 3 cycles of SMILE) PET/CT scan, and 9 of them further underwent end-treatment ( after 6 cycles of SMILE) PET/CT scan.View analysis and ΔSUVmax(%) were used to interpret 18F-FDG PET/CT images. Two-sample t test was used to analyze the difference of ΔSUVmax between PET/CT positive group and PET/CT-negative group. Survival curves were obtained using Kaplan-Meier analysis. OS and PFS were calculated and compared with the log-rank test. Results All 13 patients underwent 18 F-FDG PET/CT imaging after 3 chemotherapy cycles and were divided into PET/CT-negative group (7 patients) and positive group (6 pa-tients). ΔSUVmax of the negative group was higher than that of the positive group: (65.73±5. 95)% vs (52. 50±1.49)%;t=4.199, P<0.05. Median follow-up period was 26 (9-48) months. The median PFS and median OS of PET/CT-negative group were higher than those of PET/CT-positive group ( 39 vs 18 months, 44 vs 24 months; χ2=4.521, 4.829, both P<0.05). Conclusion Interim PET/CT scan could predict the outcome of patients with NK/T cell lymphoma.
