Evaluation of relationship between myocardial injury and left ventricular mechanical dyssynchrony using 99 Tcm-MIBI myocardial perfusion SPECT and 18 F-FDG myocardial metabolic PET imaging
10.3760/cma.j.issn.2095-2848.2017.10.005
- VernacularTitle:应用心肌灌注/代谢显像探讨心肌损伤与左室机械运动不同步化的相关性
- Author:
Shuheng LI
1
;
Yueqin TIAN
;
Xiaoxin SUN
;
Feng GUO
;
Hailong ZHANG
;
Zuoxiang HE
;
Wei FANG
Author Information
1. 100037,北京协和医学院、中国医学科学院、国家心血管病中心、阜外医院核医学科
- Keywords:
Myocardial ischemia;
Myocardial contraction;
Myocardial perfusion imaging;
Tomo-graphy,emission-computed,single-photon;
Positron-emission tomography;
Technetium Tc 99m sestamibi;
Deoxyglucose
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2017;37(10):623-626
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between myocardial injury and damage of me-chanical synchrony in the left ventricle of patients with ischemic cardiomyopathy ( ICM) using 99 Tcm-MIBI MPI and gated 18 F-FDG myocardial metabolic PET imaging. Methods A total of 113 ICM patients ( 100 males, 13 females;average age (58±10) years) underwent 99Tcm-MIBI MPI and gated 18F-FDG myocardial metabolic PET imaging from July 2015 to December 2015 in Fu Wai Hospital were retrospectively analyzed. Three-point scoring system was used for quantitative assessment of myocardial ischemia and myocardial in-farction in each segment. Total ischemic score ( TIS) and total scar score ( TSS) of 17 segments were calcu-lated in each patient. The phase bandwidth ( BW) and phase SD were derived from phase analysis. Pearson correlation analysis and logistic regression analysis were used. Results TSS were correlated with BW and SD in all 93 patients with myocardial infarction ( r values:0. 517, 0.470, both P<0.01) and also in a sub-group of 34 patients with myocardial infarction and without myocardial ischemia ( r values: 0. 647, 0. 578, both P<0.01) . There were significant correlations between TIS and BW, SD in 79 patients with myocardial is-chemia ( r values:0.392, 0.378, both P<0.01) , but no significant correlation was found in a subgroup of 20 patients with myocardial ischemia and without myocardial infarction ( r values: 0. 002, -0. 003, both P>0. 05) . Logistic regression analysis showed that the number of myocardial infarction segments and TSS were as-sociated with mechanical dyssynchrony. Conclusion Myocardial infarction is the main factor of left ventricu-lar mechanical dyssynchrony in ICM patients, but chronic myocardial ischemia has no significant influence on mechanical dyssynchrony.
