Chemical constituents from Illicium brevistylum and their anti-inflammatory activities
10.3969/j.issn.1001-1528.2017.10.019
- VernacularTitle:短柱八角化学成分及其抗炎活性的研究
- Author:
zhi Quan YE
1
;
dou Dou HUANG
;
Wei CHEN
;
shan Shan L(U)
;
na Lian SUN
Author Information
1. 福建中医药大学药学院
- Keywords:
Illicium brevistylum A.C.Smith;
chemical constituents;
isolation and identification;
anti-inflammatory activities;
NF-κB
- From:
Chinese Traditional Patent Medicine
2017;39(10):2081-2085
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from Illicium brevistylum A.C.Smith and to evaluate their anti-inflammatory activities.METHODS The n-BuOH fraction of 80％ ethanol extract from I.brevistylum was isolated and purified by silica,ODS and Sephadex LH-20,the structures of obtained compounds were identified by spectral data.Then their anti-inflammatory activities were screened.RESULTS Nine compounds were isolated and identified as (7S,8R)-3,3',5-trimethoxy-4',7-epoxy-8,5'-neolignan-4,9,9'-triol (1),methylabieta-8,11,13,15-tetraen-18-oate (2),majusanin A (3),pubeside C (4),(+)-lyoniresinol-3a-O-α-L-rhamnopyranoside (5),junipercomnoside D (6),lyoniside (7),nudiposide (8),rhyncoside A (9).The inhibition rates of compounds 2,6,9 on NF-κB were 47.81％,37.33％,33.37％,respectively.CONCLUSION Compounds 1,5,7-9 are isolated from genus Illicium for the first time,and compounds 2,6,9 exhibit good anti-inflammatory activities.
