Secondary Amyloidosis in Patient with Spinal Cord Injury: Renal and Thyroid Amyloidosis.
- Author:
Seung Tae HAN
1
;
Min Soo KIM
;
Jong Myeong YU
;
Chang Jin YEA
;
Jong Won BYUN
;
Byoung Geun HAN
;
Seung Ok CHOI
Author Information
1. Department of Internal medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. neptune@yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Amyloidosis;
Spinal cord injury
- MeSH:
Amyloidosis*;
Arthritis, Rheumatoid;
Early Diagnosis;
Extracellular Matrix;
Humans;
Kidney;
Pressure Ulcer;
Protein Folding;
Pyelonephritis;
Risk Factors;
Serum Amyloid A Protein;
Spinal Cord Injuries*;
Spinal Cord*;
Spondylitis, Ankylosing;
Thyroid Gland*
- From:Korean Journal of Nephrology
2006;25(1):109-113
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Amyloidosis is an acquired or inherited disorder with protein folding and degradation characterizing the deposition of the proteinaceous material in the extracellular matrix of one or several organs. Secondary amyloidosis resulting from the deposition of serum amyloid A protein, occurs 1-5% during the lifetime of patients with chronic inflammatory disorders such as rheumatoid arthritis and ankylosing spondylitis. In addition, chronic pyelonephritis and pressure sores in patient with spinal cord injury are documented as risk factors of secondary amyloidosis. Thus, the efforts to treat and prevent the development of secondary amyloidosis and to preserve the renal function should focus on avoiding the chronic inflammatory state and a pathologic study of doubtful organs for early diagnosis should be performed. We have experienced one case of secondary amyloidosis in patient with spinal cord injury which involves with kidney and thyroid gland.
