Clinical efficacy of Chenshi Qingfei Decoction on rheumatoid arthritis and interstitial lung disease
10.3969/j.issn.1001-1528.2017.10.008
- VernacularTitle:陈氏清肺方治疗类风湿关节炎合并肺间质病变的临床疗效
- Author:
rong Xiao TANG
1
;
Jie SHEN
;
yi Dong HE
;
Qi ZHU
;
Tao YUE
;
Ting JIANG
;
sheng Rong WANG
;
hua Xiu LIU
;
mei Hong SUN
Author Information
1. 扬州大学医学院
- Keywords:
rheumatoid arthritis (RA);
interstitial lung disease (ILD);
Chenshi Qingfei Decoction;
high-resolution computed tomography (HRCT)
- From:
Chinese Traditional Patent Medicine
2017;39(10):2029-2033
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the efficacy of Chenshi Qingfei Decoction (Pseudostellariae Radix,Ophiopogonis Radix,Adenophorae Radix,etc.) against rheumatoid arthritis and interstitial lung disease (RA-ILD).METHODS Based on Prednisolone,RA-ILD patients were randomly divided into control group and observation group by random number table and randomized block design.The observation group took Chenshi Qingfei Decoction.The treatment course was three months for both groups.Before the treatment,the activity of the disease (DAS28) was assessed and ESR,CRP,RF,CCP were measured.Before and after the treatment,high resolution-CT (HRCT) was conducted and graded,and symptoms and signs were graded.RESULTS After the treatment,the effective rate of cough,expectoration and breath hard in the syndromes of Chinese traditional medicine was 71％ in the observation group and 23％ in the control group (P ＜0.01).The effective rate of improved lung imaging by HRCT was 68％ in the observation group but 13％ in the control group (P ＜0.01).CONCLUSION Based on the immunosuppressive agents therapy in RA,Chenshi Qingfei Decoction can relieve clinical symptoms of cough,expectoration and breath hard,and reduce area and degree of interstitial lung disease by HRCT.
