Association of MTHFR C677T polymorphism with weight gain induced by risperidone in schizophrenia
10.3760/cma.j.issn.1674-6554.2017.09.012
- VernacularTitle:MTHFR基因C677T多态性与利培酮所致药源性体质量增加的关联分析
- Author:
Ning WANG
1
,
2
;
100096北京,北京回龙观医院情感障碍科
;
Gong ZHANG
;
Xinyu SUN
;
Tianlan LU
;
Zheng DONG
;
Yunlong TAN
;
Weihua YUE
Author Information
1. 100191北京,卫生部精神卫生学重点实验室暨国家精神心理疾病临床医学研究中心
2. 100096北京,北京回龙观医院情感障碍科
- Keywords:
Schizophrenia;
MTHFR gene;
Antipsychotics;
Body weight gain
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2017;26(9):830-833
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association of methylenetetrahydrofolate reductase (MTHFR)gene C677T polymorphism with weight gain induced by risperidone.Methods 356 patients with schizophrenia according to the DSM-IV criteria in this study.The height and body weight of the patients were measured before starting risperidone treatment and 8-week later.The MTHFRC677T polymorphism was genotyped using direct DNA sequencing method.Results A significant association was found between MTHFR gene C677T and body weight mass index (BMI) change after 8-week risperidone treatment.CC-carriers experienced higher BMI gain than CT/TT-carriers (CC (4.47 ± 1.09),CT (4.54 ± 1.27),TT (2.31 ± 0.75),F =5.634,P＜0.01).The frequency of allele C in bodyweight gain (＞7％) was higher than that in non-bodyweight gain groups (48.4％ vs 32.4％,x2=11.342,P＜0.01).Conclusion MTHFRC677T polymorphism is associated with risperidone induced weight gain in Chinese Han population.
