Diagnostic and prognostic value of preoperative serum carcinoembryonic antigen and carbohydrate antigen 19-9 in colorectal cancer
10.3969/j.issn.1009-9905.2017.07.005
- VernacularTitle:CEA和CA19-9在结直肠癌患者中的诊断及预后价值
- Author:
Hua YANG
1
;
Gang XIAO
;
ju Guo WU
Author Information
1. 北京医院 国家老年医学中心普外科 北京 100730
- Keywords:
Colorectal cancer;
CEA;
CA19-9;
Diagnosis;
Prognosis
- From:
Chinese Journal of Current Advances in General Surgery
2017;20(7):518-521
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the the diagnostic and prognostic value of preoperative serum carcinoembryonic antigen(pre-CEA) and carbohydrate antigen 19-9(pre-CA19-9) in colorectal cancer.Methods:382 colorectal carcinoma patients were analyzed retrospectively,who come from Beijing Hospital between June 2008 and June 2011.The clinical and histopathologic data such as age,sex,location of tumor,depth of tumor(T),lymph node metastasis(N),stage,and preoperative serum levels of CEA and CA 19-9 and prognosis were obtained.Results:The positive rate of pre-CEA,pre-CA19-9 and joint detection were 42.9％,18.6％ and 48.4％ respectively.The elevation of pre-CEA and pre-CA19-9 were significantly associated with depth of tumor,lymph node metastasis,perineural invasion,and stage (P＜0.05).Univariate analysis showed that the predictors of survival were the elevation of pre-CEA and pre-CA19-9 (P＜0.05).Multivariate analysis showed that the elevation of pre-CA19-9 and TNM were independent prognosis factors (P＜0.05).Conclusion:The pre-CEA and pre-CA19-9 have diagnostic and prognostic value in patients with colorectal cancer.Joint detection can increase the positive rate.Pre-CA19-9 was independent prognosis factors.
