Gene expression of liver nuclear receptor LRH-1 and scavenger receptor class B type I gene in cholesterol gallstone mice

VernacularTitle:胆结石小鼠肝脏核受体基因LRH-1及其调控基因SRBI的表达
Author: Song GUO ¹ ; yong Shi YANG ; yong Hong CAO ; Xiang ZHU ; Ming REN
Author Information

1. 南京中医药大学附属医院(江苏省中医院)普外科江苏南京210000
Keywords: Gallstone; Liver receptor homolog 1; Scavenger receptor B type Ⅰ
From: Chinese Journal of Current Advances in General Surgery 2017;20(7):511-514
CountryChina
Language:Chinese
Abstract: Objective:To investigate the expressions of liver receptor homolog 1 (LRH-1) and scavenger receptor B type Ⅰ (SRBI) gene in cholesterol gallstone (CGS) mice.Methods:Forty C57BL/6 mice,20 with cholesterol gallstone (GS)and 20 controls without gallstones (GSF) were enrolled in this study.mRNA and protein expression of LRH-1 and SRBI genes were determined by RT-PCR and Western blot.Results:Gallbladder walls of GS mice were thicker with increased stromal granulocyte infiltration.The expression levels of LRH-1 genes were significantly higher in GS mice than in controls(P＜0.01).The expression levels of SRBI genes were also significantly higher in GS mice than in controls(P＜0.01).Conclusion:The increased expression of LRH-1 and SRBI gene may be related to GS disease.