Study on expression of Syntaxin 8 protein in gastric carcinoma

VernacularTitle:Syntaxin8蛋白在胃癌组织中的表达及临床意义
Author: Li MA ¹ ; bao Yu CHEN ; bo Jian XUE ; Tao XU ; jun Jian TONG ; he Yun AN
Author Information

1. 首都医科大学大兴教学医院消化科北京 102600
Keywords: Gastric carcinoma; Syntaxin 8
From: Chinese Journal of Current Advances in General Surgery 2017;20(7):535-538
CountryChina
Language:Chinese
Abstract: Objective:To determine the expression of syntaxin 8 in gastric carcinoma and its clinical significance.Methods:To determine the expression levels of syntaxin 8 in gastric carcinoma and pericancerous stomach tissues of 62 patients with gastric carcinoma by immunohistochemistry,western blot.Results:Results of immunohistochemistry and western blot showed that the expression of syntaxin 8 was significantly higher than that in the adjacent pericancerous stomach tissues,and syntaxin 8 is negative in most normal tissues.The difference was statistically significant (P＜0.05).Correlation analysis found that the high expression of syntaxin 8 in gastric carcinoma tissue was not significantly related to gender,age,tumor size,TNM stage,invasion and metastasis of gastric carcinoma,but the higher expression rate was up-regulated in gastric carcinoma with distant metastasis.Conclusion:Syntaxin 8 is abnormal high expression in gastric carcinoma tissues,and is related to the occurrence and development of gastric carcinoma.It may also be a potential target for gastric carcinoma diagnosis and treatment.