Influence of magnesium valproate and quetiapine separately combined with lithium carbonate on BRMS score,PANSS score and adverse effects of patients with manic episode of bipolar disorder in puberty
10.3760/cma.j.issn.1008-6706.2017.22.027
- VernacularTitle:丙戊酸钠与喹硫平联合碳酸锂对双相情感障碍躁狂发作患者BRMS评分、PANSS评分的影响比较
- Author:
Yali HAN
1
;
Minqiao ZHANG
;
Yan HE
;
Daping JIANG
Author Information
1. 315700,浙江省象山县第三人民医院精神科
- Keywords:
Bipolar disorder;
Magnesium valproate;
Quetiapine;
Lithium carbonate
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(22):3466-3469
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of magnesium valproate and quetiapine separately combined with lithium carbonate on BRMS scores,PANSS scores and adverse effects of patients with manic episode of bipolar disorder in puberty. Methods 100 patients with manic episode of bipolar disorder in puberty were chosen and randomly divided into two groups according to the digital table. Group A ( 50 children ) was given magnesium valproate,and group B (50 children) was given quetiapine on the basis of lithium carbonate. The clinical efficacy,the BRMS score,PANSS score and WCST score before and after treatment and the incidence of adverse effects of the two groups were compared. Results There was no significant difference in clinical efficacy between the two groups (94. 00% vs. 90. 00%),(χ2 =1. 31,P>0. 05). After treatment for 2 weeks,the BRMS score,PANSS score and WCST score of group B were significantly better than those of group A and before treatment(t=2. 45,3. 16;2. 71,3. 26,2. 79, 3. 36,all P<0. 05). 6 weeksafter treatment,there were no significant differences in the BRMS score,PANSS score and WCST score between the two groups(t=1. 20,1. 08,1. 19,all P<0. 05). There was no significant difference in the incidence rate of adverse effects between the two groups(χ2 =1. 49,P>0. 05). Conclusion Two kinds of bigeminy drug therapy in the treatment of patients with manic episode of bipolar disorder in puberty possess the clinical effects and safety,and quetiapine combined with lithium can help to shorten the onset time and higher the compliance degree.
