Evaluation changes of regional cerebral glucose metabolism in patients with Alzheimer's disease
10.3969/j.issn.1002-1671.2017.10.002
- VernacularTitle:阿尔茨海默病患者脑葡萄糖代谢变化PET/CT研究
- Author:
Xiaoyi DUAN
1
;
Jungang GAO
;
Xiang LIU
;
Lu BAI
;
Youmin GUO
Author Information
1. 西安交通大学第一附属医院医学影像科
- Keywords:
Alzheimer's disease;
glucose metabolism;
positron emission tomography/computed tomography
- From:
Journal of Practical Radiology
2017;33(10):1499-1503
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characteristics and significance signification of changes of cerebral glucose metabolism in patients with Alzheimer's disease (AD).Methods Seventeen patients diagnosed with AD based on standard clinical diagnostic criteria (AD group),and 15 healthy volunteers as normal control group (HC group)were enrolled in this study.Positron emission tomography (PET)were performed in both groups and three-dimensional reconstruction images were obtained.The visual evaluation,regions of interesting (ROI)technology and brain function analysis software were used to analyze PET results data in of each group.Results ①In AD group,glucose metabolisam was decreased and mainly distributed in the parietal lobe,temporal lobe,frontal cortex,posterior cingultate and hippocampus,but not in occipital lobe,basal ganglia,thalamus and cerebellum nuclei basales,thalamus and opisthencephalon.Ssomatic sensation and motor functionand were not affected.②Compared with mild AD patients,glucose metabolism inof moderate and severe AD patients was decreased more significantly in parietal lobe,temporal lobe,frontal cortex,posterior cingultate and hippocampus,with a wider range of lesionsthe range also expanded,and visual area and speech centerpartly followed by the disorder of visual center and speech center may bewere involved in some patients.③The built-in brain function analysis software of PET system software carried by PET system was more objectiveprecise and accurate than visual evaluation or and ROI technology,can accurately reflected the changes in brain glucose metabolism which and iwas suitable for popularization and application.Conclusion Because the distribution of impaired glucose metabolism in cerebral cortex hads certain characteristics and regularity laws in AD patients.18 F-FDG PET imaging can maybe meaningful valuable in diagnosis,differential diagnosis and therapeutic evaluation in AD.
