Dynamic contrast-enhanced MRI in the differential diagnosis of high-grade gliomas and metastasis
10.3969/j.issn.1002-1671.2017.10.003
- VernacularTitle:DCE-MRI在高级别脑胶质瘤与脑转移瘤中的鉴别诊断
- Author:
Wei ZHANG
1
;
Qinglan SUI
;
Lei NIU
;
Huawei SU
;
Xiaoyan XING
;
Jing ZHANG
Author Information
1. 中国中医科学院西苑医院放射科
- Keywords:
dynamic contrast-enhanced magnetic resonance imaging;
high-grade glioma;
brain metastasis;
pharmacokinetic parameters
- From:
Journal of Practical Radiology
2017;33(10):1504-1506,1519
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the value of dynamic contrast-enhanced MRI (DCE-MRI)in differential diagnosis of high-grade gliomas (HGG)and metastasis.Methods 27 cases of HGG and 46 cases of metastasis were enrolled.All patients took contrast MRI and DCE-MRI before operation.Using the pharmacokinetic model of Extended Tofts Linear to quantitative analyze the data,volume transfer constant (Ktrans ),extracellular extravascular volume fraction (Ve )and blood plasma fraction (Vp )of the lesion's solid components and perilesional edam were obtained.Ktrans value,Ve value and Vp value were compared to judge whether there were significant differences between the two kinds of tumors.Results The values of the Ktrans ,Ve and Vp in parenchyma of HGG and metastasis were not statistically significant (P >0.05).The values of Ktrans and Ve in peritumoral edema of HGG were significantly higher than that of metastasis (P <0.05);Vp values in the peritumoral edema of HGG were lower than that of metastasis,but the difference was not statistically significant (P >0.05). Conclusion DCE-MRI can effectively distinguish HGG from metastasis through quantitative analysis of the perilesional edema.
