Research advances in the effects of thrombospondin-1 on the progress of diabetic retinopathy
10.13389/j.cnki.rao.2017.0250
- VernacularTitle:血小板反应蛋白1在糖尿病视网膜病变中的作用
- Author:
Le DONG
1
;
Cheng Peng XUE
;
Peng Zhi YOU
Author Information
1. 南昌大学第二附属医院眼科
- Keywords:
diabetic retinopathy;
thrombospondin-1;
neovascularization
- From:
Recent Advances in Ophthalmology
2017;37(10):984-987
- CountryChina
- Language:Chinese
-
Abstract:
Thrombospondin-1,an important extracellular matrix glycoprotein,is recognized as an effective endogenous angiogenesis inhibitor and can affect and regulate the adhesion,motility and proliferation of endothelial cells,as well as closely correlated with the development and progress of tumor and neovascular diseases.In recent years,it has been found that Tsp-1 is associated with many pathologic changes in diabetic retinopathy and is critical for the maintenance of retinal vascular balance.And the mechanism of action of TSP-1 and its role in the development of DR will be reviewed in this paper.
