The clinical outcome of renal transplantation with a poor HLA matched living kidney donors.
- Author:
Yong Hun SIN
1
;
Hyun Ju KIM
;
Hwa Mok LEE
;
Joon Seok OH
;
Hyun Cheol HWANG
;
Dong Han IM
;
Ji Hwan KIM
;
Chang Soo PARK
;
Mi Jeong PARK
;
Hoe Joo OH
;
Yong Ki PARK
;
Joong Kyung KIM
;
Gun Ung JEON
Author Information
1. Department of Internal Medicine, Bong Saeng Hospital, Busan, Korea. syhpmj@hanmail.net
- Publication Type:Original Article
- Keywords:
Renal transplantation;
HLA
- MeSH:
Allografts;
Creatinine;
Graft Survival;
Humans;
Incidence;
Kidney Transplantation*;
Kidney*;
Medical Records;
Research Design;
Survival Rate;
Tissue Donors*;
Transplants
- From:Korean Journal of Medicine
2005;69(4):402-409
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Poor HLA matched donors may become an additional organ source for renal transplantation. This study is conducted to predict the clinical outcomes of renal transplantation in a poor HLA matched group (0 or 1 or 2 HLA matching) by comparing them with those of HLA haploidentical group. METHODS: This study compared a poor HLA matched group (N=89) with HLA haploidentical group (N=79) to analyze differences between two groups in graft survival, incidence of acute rejection, cause of graft failure, posttransplant serum creatinine at 1, 2, 3, 5 years. Total 168 cases, appeared in the medical records for more than six months in Bong-Saeng Hospital, from December, 1984 to March, 2004 were traced and identified as relevant cases for this study. RESULTS: Allograft survival rate at 1, 3, 5, 10 years for poor HLA matched group and HLA haploidentical group were 100%, 98.6%, 95.4%, 72.5% and 100%, 100%, 96.1%, 86.2% (p=not significant) respectively. Acute rejection developed in 25.8% of poor HLA matched group versus 18.9% of HLA haploidentical group (p=not significant). The most common causes of graft failure in both groups were chronic rejection. CONCLUSIONS: It should be actively encouraged to consider renal transplantation in a poor HLA matched group as the results of this study support that the clinical outcomes of renal transplantation in a poor HLA matched group are equivalent to those of HLA haploidentical group.
