Effects of stachydrine hydrochloride on experimental acute cerebral in-farction in rats
10.3969/j.issn.1000-4718.2017.10.006
- VernacularTitle:盐酸水苏碱对实验性急性脑梗死大鼠的治疗作用
- Author:
feng Hua LIANG
1
;
Juan WANG
;
Jing XIE
;
Juan YU
;
Jing SHEN
;
Feng TIAN
;
hong Chun LIU
;
li Hui ZHANG
Author Information
1. 新疆石河子大学医学院第一附属医院神经内科
- Keywords:
Stachydrine hydrochloride;
Acute cerebral infarction;
Wnt/β-catenin signaling pathway
- From:
Chinese Journal of Pathophysiology
2017;33(10):1768-1772
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the therapeutic effect of stachydrine hydrochloride on experimental acute cerebral infarction in rats and to explore the underlying mechanisms .METHODS:SD rats ( n=75) were randomly divided into 5 groups:sham group, cerebral infarction model group , and stachydrine hydrochloride (10 mg/kg, 20 mg/kg and 40 mg/kg) treatment groups .After the establishment of cerebral infarction model , the rats were given stachydrine hydrochloride at dose of 10 mg/kg, 20 mg/kg or 40 mg/kg by gavage daily for 14 d.The impairment of neurological function in each group was scored .The cerebral infarction volume and brain water content were measured .Moreover , the protein levels of β-cate-nin, cyclin D1, glycogen synthase kinase 3β(GSK-3β) and p-GSK-3βin the brain tissues were detected by Western blot . RESULTS:Compared with cerebral infarction group , the score of neurological function impairment , cerebral infarction volume and brain water content were significantly decreased in stachydrine hydrochloride treatment groups .In addition , the protein levels of β-catenin, cyclin D1 and p-GSK-3βwere markedly increased after stachydrine hydrochloride treatment . CONCLUSION:Stachydrine hydrochloride protects against experimental acute cerebral infarction through activation of Wnt/β-catenin signaling pathway .
