Structural and functional brain alterations in drug-free schizophrenia patients:a multimodal Meta-analysis
10.3969/j.issn.1002-1671.2017.10.001
- VernacularTitle:精神分裂症患者脑结构及功能的多模态影像Meta分析
- Author:
Xin GAO
1
;
Wenjing ZHANG
;
Li YAO
;
Yuan XIAO
;
Jieke LIU
;
Lu LIU
;
Su LÜ
Author Information
1. 四川大学华西医院放射科
- Keywords:
schizophrenia;
gray matter;
multimodal;
network;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2017;33(10):1493-1498
- CountryChina
- Language:Chinese
-
Abstract:
Objective By conducting a Meta-analysis on morphometric and functional imaging studies in drug-free patients,to examine the degree of overlap between anatomical and functional brain changes in schizophrenia.Methods A systematic search was conducted using PubMed,Embase,Web of Science and The Cochrane Library to identify relevant previous publications.A multimodal analysis was conducted using "Seed-based d Mapping"software.Results Fourteen structural MRI studies comprising 446 drug-free patients and 461 healthy controls,and 15 functional MRI and PET studies with 360 drug-free patients and 396 controls were enrolled in the present study. Multimodal analysis revealed considerable overlap between anatomical and functional changes,mainly in fronto-temporal regions,bilateral medial posterior cingulate/paracingulate gyrus,bilateral insula,basal ganglia,and left cerebellum.Conclusion The overlapping anatomical and functional brain abnormalities mainly in the default-mode network (DMN)and the auditory network (AN)in drug-free schizophrenia patients. The pattern of changes differed in these networks.Decreased gray matter was associated with decreased activation within the DMN, while decreased gray matter was associated with increased activation within the AN.These discrete patterns suggest different pathophysiological changes impacting structure/function relationships within different neural networks in schizophrenia.
