The value of semiquantitative parameters of DCE-MRI in predicting and monitoring efficacy of concurrent chemoradiotherapy in laryngeal and hypopharyngeal carcinoma
10.3969/j.issn.1002-1671.2017.10.006
- VernacularTitle:DCE-MRI半定量参数预测和监测喉癌和下咽癌同步放化疗疗效的价值
- Author:
Xinyi CHEN
1
;
Meng LIN
;
Dehong LUO
;
Minming ZHANG
Author Information
1. 浙江大学医学院附属第二医院放射科
- Keywords:
laryngeal carcinoma;
hypopharyngeal carcinoma;
dynamic contrast-enhanced magnetic resonance imaging;
chemoradiotherapy;
efficacy
- From:
Journal of Practical Radiology
2017;33(10):1515-1519
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of semi-quantitative parameters of dynamic contrast-enhanced MRI (DCE-MRI)in predicting and monitoring therapeutic efficacy of concurrent chemoradiotherapy in laryngeal and hypopharyngeal carcinoma.Methods Forty-four patients with pathologically confirmed laryngeal and hypopharyngeal squamous cell carcinoma were collected.Time signal intensity curves (TIC)and related semi-quantitative parameters were obtained before (point 1 ),during (point 2)and after (point 3 )treatment. Tumor remission were assessed at the end of treatment and the statistical analyses were performed using SPSS.Results Twenty two patients had a complete remission as CR group and 22 had a partial remission as PR group.The parameters of time to peak (TTP), maximum signal enhancement ratio (SERmax ),positive enhancement integral (PEI),SER70 and SER84 at point 1 were higher than those at point 2,and there were significant differences between two groups (P <0.05).The values of SERmax ,SER42 ,SER56 ,SER70 and SER84 before treatment were higher in CR group than those in PR group,exhibiting significant differences between two groups (P <0.05).ROC curve analysis showed the threshold for SER56 was set to ≥129.4％ to predict complete remission,and the sensitivity and specificity were 60％ and 86.4％,respectively.Comparison of remission rates among different types of TIC showed complete remission rates in typeⅠTIC and type Ⅲ TIC were 87.5％ and 39.3％,respectively,exhibiting a significant difference between two groups (P =0.041). Conclusion TIC types and semi-quantitative parameters of DCE-MRI can predict therapeutic efficacy of concurrent chemoradiotherapy in laryngeal and hypopharyngeal carcinoma,SER56 is the most important predictive semi-quantitative parameter,and prognosis is much better in typeⅠTIC than type Ⅲ TIC before treatment.
