A case of plasmablastic lymphoma in the nasal cavity in a human immunodeficiency virus-negative patient.
- Author:
Taeg Soo KIM
1
;
Jeong Min KANG
;
Hyun Woo KIM
;
Yong Gil KIM
;
Jooryung HUH
;
Yong Ju JANG
;
Cheolwon SUH
Author Information
1. Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. csuh@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Lymphoma;
Large cell;
Plasmablastic;
HIV-negative;
Nasal cavity
- MeSH:
Antigens, CD45;
B-Lymphocytes;
HIV;
Humans*;
In Situ Hybridization;
Korea;
Lymph Nodes;
Lymphoma*;
Lymphoma, B-Cell;
Middle Aged;
Mouth;
Mucin-1;
Nasal Cavity*;
RNA;
T-Lymphocytes
- From:Korean Journal of Medicine
2005;69(4):446-450
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Plasmablastic lymphoma is a recently identified entity that is considered to be a type of diffuse large B-cell lymphoma with a unique immunophenotype and a predilection for the oral cavity of human immunodeficiency virus (HIV) positive patients. We report a case of plasmablastic lymphoma presenting in nasal cavity of a 48-year-old, HIV-negative man. Cytologic and histologic examinations demonstrated a large cell lymphoma with plasmablastic differentiation. The tumor cells were positive for CD138, epithelial membrane antigen, but lacked expression of leukocyte common antigen, T-cell, and B-cell markers. Abundant Epstein-Barr virus-encoded RNA transcripts were identified by in situ hybridization. The lambda-light-chain restriction was demonstrated by in situ hybridization. These findings were compatible with plasmablastic lymphoma. Subsequent whole body FDG-PET scan revealed hypermetabolic lesions in the nasal cavity and left cervical lymph nodes level II,III,IV. To our knowledge, this is the first case of plasmablastic lymphoma in Korea.
