The evaluation of different stages of TNM in prognosis of appendiceal neuroendocrine tumors
10.11958/20170468
- VernacularTitle:TNM不同分期在阑尾神经内分泌肿瘤患者预后评估中的价值
- Author:
ze Ying XIAO
1
;
jie Dong BAN
;
ming Jian WEI
;
ning Sheng ZHANG
Author Information
1. 天津市公安医院普通外科 300020
- Keywords:
neuroendocrine tumors;
appendix;
neoplasm staging;
prognosis;
Kaplan-Meiers estimate;
TNM staging
- From:
Tianjin Medical Journal
2017;45(10):1080-1082
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic value of different stages of TNM in patients with appendiceal neuroendocrine tumors (NETs). Methods The clinical data of 40 cases of NETs were analyzed, and follow-up data were staged by the ENETS and AJCC TNM staging system. Kaplan-Miere survival curves were used to compare survival differences in patients with different stages of TNM. Results Of the 40 patients, no one was diagnosed as appendiceal NETs before surgery. Twenty-one patients were diagnosed as acute appendicitis, 16 were diagnosed as chronic appendicitis and 3 were suspected as appendiceal tumors due to thickening of the lumen before surgery. No clinical manifestations were found in 40 patients before surgery including diarrhea, abdominal pain, facial flushing, asthma-like seizures and other carcinoid syndrome performance. All patients underwent appendectomy, and appendix NETs were diagnosed by pathology after surgery. In 40 appendical NETs patients, 15 cases were classified as stageⅠ(37.5%), 10 cases were classified as stageⅡA (25%), 2 cases were classified as stageⅢA (5%), 13 cases were classified at stageⅢB (32.5%), and no patients were classified as stageⅣ. The median survival times (months) were 27, 22, 21 and 18 for patients with different stages, and there were no significant differences in survival times between four stages (χ2=0.8988,P>0.05). Conclusion The clinical features of appendical NETs are nonspecific. The diagnosis of appendical NETs is based on pathological examination and immunohistochemistry. There are no correlation between different TNM stages and prognosis of patients.
