Relationship between neutrophil-to-lymphocyte ratio and urine-to-creatinine ratio in patients with type 2 di-abetes mellitus
10.16571/j.cnki.1008-8199.2017.10.010
- VernacularTitle:2型糖尿病患者中性粒细胞/淋巴细胞比值与尿白蛋白/肌酐比值的相关性研究
- Author:
ming Yi TIAN
1
;
Qiang LU
;
zai Fu YIN
;
Tao LI
;
yuan Hong GU
;
Rui WANG
;
ru Jun LIU
;
Rui WANG
Author Information
1. 秦皇岛市第一医院内分泌科
- Keywords:
Neutrophils;
Lymphocytes;
Type 2 diabetes mellitus;
Diabetic nephropathies;
Albuminuria
- From:
Journal of Medical Postgraduates
2017;30(10):1061-1064
- CountryChina
- Language:Chinese
-
Abstract:
Objective Little study has been done on the relationship between neutrophil-to-lymphocyte ratio ( NLR) and u-rine-to-creatinine ratio ( UACR) in patients with type 2 diabetes mellitus ( T2DM) .The article aimed to investigate the relationship be-tween NLR and UACR in T2DM patients. Methods 121 T2DM patients in our hospital from July 2015 to December 2015 were en-rolled and divided into patients with diabetic kidney disease (DKD) group(n=49) and non-DKD group(n=72).In accordance with UACR levels, the patients were divided into normoalbuminuria group ( n=72, male UACR<2.5 mg/mmol, female UACR<3.5 mg/mmol), microalbuminuria group ( n=33, male 2.5 mg/mmol≤UACR<30 mg/mmol, female 3.5 mg/mmol≤UACR<30 mg/mmol), and high-grade proteinuria group ( n=16, UACR≥30 mg/mmol ) . Clinical data and biochemical index were collected , which includes course of diabetes , glycosylated hemoglobin ( HbA1c ) , 25-OH vita-min D, and fasting/postprandial blood glucose/insulin /c-peptide, followed by analysis on the risk factors of DKD . Results NLR was significantly increased in DKD group compared to non-DKD group (2.14±1.06 vs 1.76±0.76, P=0.025) and was in significant relation with UACR (r=0.273, P=0.003).No significant difference was found among patients with normoalbuminuria , microalbuminuria, and macroalbuminuria(P>0.05).Logistic regression analysis revealed NLR (OR=1.829, 95%CI:1.051-3.183, P=0.033), course of di-abetes (OR=1.142,95%CI:1.062-1.229, P<0.001) and lipoprotein a (OR=1.026, 95%CI:1.001-1.051, P=0.039) as risk fac-tors for DKD. Conclusion It's the first report of the relationship between NLR and UACR , indicating NLR should be paid attention in patients with T2DM.
