Effects of aspirin and clopidogrel on the risk of upper gastrointestinal bleeding in patients with cardiovascular and cerebrovascular diseases
10.3969/j.issn.1005-1678.2017.10.061
- VernacularTitle:阿司匹林与氯吡格雷对心脑血管疾病患者上消化道出血风险的影响研究
- Author:
Jing KONG
1
;
lin Xiao XIE
;
ping Lu LIU
;
Jing MA
;
wei Hua HU
;
shi Qiu ZHANG
Author Information
1. 杭州市第三人民医院 心血管内科
- Keywords:
upper gastrointestinal bleeding;
clopidogrel;
aspirin;
cardiovascular and cerebrovascular diseases
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(10):153-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of aspirin and clopidogrel on the risk of upper gastrointestinal bleeding in patients with cardiovascular and cerebrovascular diseases. Methods 116 cases of patients with upper gastrointestinal bleeding and cardiovascular disease as research subjects. 86 cases of patients used antiplatelet drugs (drug group), 30 cases didn't use antiplatelet drugs (non-drug group). In the drug group, 30 patients with aspirin alone (group A), 24 patients with clopidogrel alone (group B) and 32 patients with aspirin and clopidogrel (group C) . Compared the upper gastrointestinal bleeding in each group of patients. Results The incidence of abdominal pain in the drug group was significantly lower than non-drug group (P<0.05). However, there was no significant difference in the incidence of bloating, nausea, vomiting, acid reflux compared with non - drug group. There were no significant differences in the endoscopic manifestations of gastrointestinal bleeding between the drug group and the non-drug group. The incidence of severe gastrointestinal bleeding in the drug group was 47.67%, significantly higher than that in the non-drug group (26.67%)(P<0.05). A, B, C three groups of patients with severe gastrointestinal bleeding rate and bleeding patterns were no significant difference. There was no significant difference in the total effective rate of gastrointestinal bleeding between the drug group and the non-drug group. Conclusion Antiplatelet drugs may increase the risk of upper gastrointestinal bleeding in patients with cardiovascular and cerebrovascular diseases, but aspirin and clopidogrel alone or in combination had no significant effect on the degree of gastrointestinal bleeding.
