Therapeutic effect of QQL prescription on type 2 diabetic rats
10.3969/j.issn.1000-4718.2017.10.010
- VernacularTitle:青钱柳降糖组方对2型糖尿病大鼠的治疗作用
- Author:
mei Xin JIANG
1
;
xiong Qiu LIN
;
dong Guo HE
;
hua Xing HOU
;
xin Zhi SHAN
;
min Yao DU
Author Information
1. 佛山市南海经济开发区人民医院妇产科
- Keywords:
Cyclocarya paliurus;
Antidiabetics;
Type 2 diabetes;
Insulin
- From:
Chinese Journal of Pathophysiology
2017;33(10):1794-1800
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the therapeutic effect of Qingqianliu ( QQL) antidiabetic prescription , contai-ning Cyclocarya paliurus, on type 2 diabetic rats.METHODS: Ten rats were randomly chosen as normal control group , and other rats were used to establish diabetic rat models by high-fat diet feeding plus streptocin intraperitoneal injection . Successfully modeling rats were randomly divided into high (300 mg· kg -1· d-1), medium (150 mg· kg-1· d-1) and low (75 mg· kg-1· d-1) doses of QQL treatment groups, and model control group (10 rats in each group).The rats re-ceived daily treatment for 6 weeks.Meanwhile, the therapeutic effect of QQL on these type 2 diabetic rats were evaluated via the body weight , the levels of serum glucose , insulin and glycosylated hemoglobin , the glucose tolerance , the pathologi-cal changes of pancreatic islands , antioxidative indexes and inflammaory factors .RESULTS:Compared with model control group, the body weight, serum insulin, glucose tolerance, serum SOD and serum GSH were increased , the serum glucose, glycosylated hemoglobin , MDA, IL-1βand TNF-αwere decreased , and the pathological changes of pancreatic islands were improved in type 2 diabetic rats with QQL treatment at high and low doses (P<0.05 or P<0.01).CONCLUSION:The QQL reduces the blood glucose , improves the glucose tolerance , and attenuates the damage of pancreatic islands .Its me-chanism may be related to antioxidative and anti-inflammatory effects .
