Analysis of sedative effect of dexmedetomidine combined with remifentanil in patients with mechanical ventilation after ICU surgery
10.3969/j.issn.1005-1678.2017.10.068
- VernacularTitle:右美托咪定复合瑞芬太尼对ICU术后机械通气患者的镇静效果分析
- Author:
Ping WANG
1
;
sheng Wei JIN
;
mu Cai WANG
;
Kai XUN
Author Information
1. 宁海县第一医院 ICU
- Keywords:
ICU;
postoperative;
mechanical ventilation;
dexmedetomidine;
remifentanil
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(10):169-170
- CountryChina
- Language:Chinese
-
Abstract:
Objective investigate the analgesic effect of dexmedetomidine combined with remifentanil in patients with mechanical ventilation after ICU surgery. Methods 120 patients with ICU underwent mechanical ventilation were divided into control group (propofol combined remifentanil) and observation group (dexmedetomidine remifentanil) according to the random number table method, 60 cases each group. Record the two groups of total sedation time, withdrawal time after the withdrawal, analgesic effect, adverse reactions. Results The scores of SAS score and CPOT were (3.98±0.52) and (2.23±1.04), respectively, which were significantly lower than those in the control group (4.36±0.96) and (3.46±2.23), respectively (P<0.05). (691.28±236.58) min and (1.22±0.05) min were significantly shorter than those in the control group (2642.33±341.58) min, (3.56±0.74) min, P<0.05, respectively. The adverse reaction rate was 3.33% (2/60) in the observation group, which was significantly lower than that in the control group (13.33%, 8/60),( χ2=3.92, P=0.04). Conclusion ICU postoperative mechanical ventilation patients with dexmedetomidine combined with remifentanil has a good analgesic effect, and is conducive to the patient wake up, less adverse reactions, with a certain safety.
