Clinical study of two routes of vancomycin assisted continuous drainage in the treatment of secondary intracranial infection after traumatic brain injury
10.3969/j.issn.1005-1678.2017.10.106
- VernacularTitle:万古霉素两种给药途径辅助持续引流治疗脑外伤继发颅内感染的临床研究
- Author:
gang Zhi GUO
1
;
li Ke ZHANG
Author Information
1. 天津市宝坻区人民医院
- Keywords:
traumatic brain injury secondary intracranial infection;
vancomycin;
intrathecal injection;
intravenous drip;
continuous drainage;
application effect
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(10):246-247
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of continuous infusion of vancomycin in the treatment of intracranial infection secondary to traumatic brain injury by intrathecal injection and intravenous infusion. Methods 96 patients with traumatic brain injury from December 2015 to March 2017 were randomly divided into study group and control group, the patients were randomly divided into study group and control group (n=48).The study group of patients with continuous drainage combined with vancomycin intrathecal injection treatment, the control group of patients with continuous drainage combined with vancomycin intravenous infusion. The clinical effects of two groups of patients with secondary intracranial infection after traumatic brain injury were recorded. Results After treatment, the total effective rate of clinical treatment in the study group was as high as 89.58%, compared with 70.83% in the control group, the differences were statistically significant(P<0.05). Conclusion Vancomycin intrathecal injection combined with continuous drainage is effective in the treatment of secondary intracranial infection after brain injury, and it is beneficial to protect the quality of life and life safety of the patients.
